Publications & Scientific Reports

Below you will find detailed studies on active ingredients and clinical trial results.

LONG-TERM ANALYSIS RESULTS: LARENS LIFTING FACE CREAM Discoloration after 4th week of use

LONG-TERM ANALYSIS RESULTS: LIPOCOLL HA HYDRO SERUM AND LIPOCOLL HYDRO SERUM + LIFTING FACE CREAM

LONG-TERM ANALYSIS RESULTS: LARENS LIFTING FACE CREAM Wrinkles after 4th week of use

Scientific research on fish collagen peptides

CERTIFICATE of tolerance for sensitive skin

pH level of Larens products

pH level of Larens Professional products

100 uses of biopeptide serum spray

Become a supercentenarian

LONG-TERM ANALYSIS RESULTS: LARENS LIFTING FACE CREAM Discoloration after 1st week of use

An Estimation of the Biological Properties of Fish Collagen in an Experimental In Vitro Study. Aleksandra Kuzan, Anna Smulczyńska-Demel, Agnieszka Chwiłkowska, Jolanta Saczko, Andrzej Frydrychowski, Marzena Dominiak.

Identification of Small Peptides of Acidic Collagen Extracts from Silver Carp Skin and Their Therapeutic Relevance, Diana Wojtkowiak, Andrzej F Frydrychowski, Jakub Hadzik, Marzena Dominiak.

Katarzyna Adamiak, Alina Sionkowska. Current methods of collagen cross-linking: Review. International Journal of Biological Macromolecules. International Journal of Biological Macromolecules 2020, 161, 550–560. IF: 5.162

Alina Sionkowska, Katarzyna Adamiak, Katarzyna Musiał, Magdalena Gadomska. Collagen Based Materials in Cosmetic Applications: A Review. Materials 2020, 13, 4217. IF: 3.057,

Alina Sionkowska, Katarzyna Lewandowska, Katarzyna Adamiak. The Influence of UV Light on Rheological Properties of Collagen Extracted from Silver Carp Skin. Materials 2020, 13, 4453. IF: 3.057

Katarzyna Adamiak, Katarzyna Lewandowska, Alina Sionkowska. The Infuence of Salicin on Rheological and Film-Forming Properties of Collagen. Molecules 2021, 26, 1661. IF: 3.267

Katarzyna ADAMIAK, Alina SIONKOWSKA. The influence of UV irradiation on fish skin collagen films in the presence of xanthohumol and propanediol. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2022, 282, 121652

Mahesh B., Lokesh H. R, Kathyayani D., Alina Sionkowska, Channe Gowda D., Katarzyna Adamiak. Interaction between synthetic elastin-like polypeptide and collagen: Investigation of its miscibility and physicochemical properties. Journal of Molecular Liquids

Katarzyna Adamiak, Marzanna Kurzawa, Alina Sionkowska. Physicochemical performance of Collagen modified by Melissa officinalis extract. Cosmetics. At the Editor.

Sionkowska Alina, Adamiak Katarzyna, Gadomska Magdalena, Musiał Katarzyna. Theuse of collagen and collagen peptides in biomedicine and cosmetics. Biophysics and Medicine. Red. Leszek Kubisz, Wydawnictwo Naukowe Uniwersytetu Medycznego im. Karola Marcinkowskiego, 2020, Poznań. 978-83-7597-408-9.

Maghraby, G. M. E., Williams, A. C., & Barry, B. W. (2006). Can drug‐bearing liposomes penetrate intact skin?. Journal of Pharmacy and Pharmacology, 58(4), 415-429.

Alexander, M. Y., & Akhurst, R. J. (1995). Liposome-mediated gene transfer and expression via the skin. Human molecular genetics, 4(12), 2279-2285.

Kirjavainen, M., Urtti, A., Jääskeläinen, I., Suhonen, T. M., Paronen, P., Valjakka-Koskela, R., ... & Mönkkönen, J. (1996). Interaction of liposomes with human skin in vitro—the influence of lipid composition and structure. Biochimica et Biophysica Acta (BBA)-Lipids and Lipid Metabolism, 1304(3), 179-189

Weiner, N., Lieb, L., Niemiec, S., Ramachandran, C., Hu, Z., & Egbaria, K. (1994). Liposomes: a novel topical delivery system for pharmaceutical and cosmetic applications. Journal of Drug Targeting, 2(5), 405-410

Verma, D. D., Verma, S., Blume, G., & Fahr, A. (2003). Particle size of liposomes influences dermal delivery of substances into skin. International journal of pharmaceutics, 258(1-2), 141-151

The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin Young-Mi Kim, Eun-Cheol Kim, Youngho Kim.

Lysyl oxidases: from enzyme activity to extracellular, matrix cross-links, Sylvain D. Vallet and Sylvie Ricard-Blum

Human lysyl oxidase-like 2, Hee-Jung Moon, Joel Finney, Trey Ronnebaum, Minae Mure

Collagen Supplementation for Joint Health: The Link between Composition and Scientific Knowledge, Daniel Martínez-Puig *, Ester Costa-Larrión, Nuria Rubio-Rodríguez and Patricia Gálvez-Martín.

Synergistic effect of copper and amino acid mixtures on the production of extracellular matrix proteins in skin fibroblasts Ki Wung Chung, Seh Hyon Song, Man‑seok Kim

Miyata, T.; Taira, T.; Noishiki, Y. Collagen engineering for biomaterial use, Clin. Mater. 1992, 9, 139–148

Cen, L.; Liu, W.; Cui, L.; Zhang, W.; Cao, Y. Collagen Tissue Engineering: Development of Novel Biomaterials and Appli‐ cations, Pediatr. Res. 2008, 63, 492–496.

Parenteau‐Bareil, R.; Gauvin, R.; Berthod, F. Collagen‐Based Biomaterials for Tissue Engineering Applications. Mater. 2010, 3, 1863–1887

R. Nair, M. Sevukarajan, T. Mohammed, C.K. Badivaddin, A. Kumar, Collagen based drug delivery systems: A Review. J Innov Trends Pharm Sci. 1 (2010) 288–304.

A. Bhattacharjee, M. Bansal, Collagen Structure: The Madras Triple Helix and the Current Scenario, critical review. IUBMB Life, 57(2005) 161 – 172

Kamila A. Czubak, Halina M. Żbikowska, Struktura, funkcja i znaczenie biomedyczne kolagenów, „Annales Academiae Medicae Silesiensis”, 68 (4), 2014, s. 245–254.

KaurJ., ReinhardtD.P., Extracellular Matrix (ECM) Molecules, [w:] Vishwakarma i inni red., Stem Cell Biology and Tissue Engineering in Dental Sciences, Elsevier, 2015, s. 27, 30–33, ISBN 978-0-12-397157-9.

LodishH. i inni, Molecular Cell Biology, W. H. Freeman and Company, 2016, s. 948, ISBN 978-1-4641-8339-3

Cescon M, Chen P, Castagnaro S, Gregorio I, Bonaldo P. Lack of collagen VI promotes neurodegeneration by impairing autophagy and inducing apoptosis during aging. Aging (Albany NY). 2016 May;8(5):1083-101

Cheng IH, Lin YC, Hwang E, Huang HT, Chang WH, Liu YL, Chao CY. Collagen VI protects against neuronal apoptosis elicited by ultraviolet irradiation via an Akt/phosphatidylinositol 3-kinase signaling pathway. Neuroscience. 2011 Jun 2;183:178-88

Koizumi, S., Inoue, N., Sugihara, F., Igase, M. Effects of Collagen Hydrolysates on Human Brain Structure and Cognitive Function: A Pilot Clinical Study. Nutrients, 2020, 12

Cheng JS, Dubal DB, Kim DH, Legleiter J, Cheng IH, Yu GQ, Tesseur I, Wyss-Coray T, Bonaldo P, Mucke L. Collagen VI protects neurons against Abeta toxicity. Nat Neurosci. 2009 Feb;12(2):119-21.

Zague V, de Freitas V, da Costa Rosa M, de Castro GÁ, Jaeger RG, Machado-Santelli GM. Collagen hydrolysate intake increases skin collagen expression and suppresses matrix metalloproteinase 2 activity. J Med Food. 2011 Jun;14(6):618-24